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Actually, no, it wasn’t done with just a slide rule! The calculations were most likely done with large mainframes! The Apollo Program started in 1961 with the famous speech by President Kennedy.
http://en.wikipedia.org/wiki/Apollo_program
At that time, the prevailing tools for orbital and other NASA calculations were large mainframes, the IBM 7090 and similar scientific computers from other vendors. By 1964, IBM had introduced System\360.
http://en.wikipedia.org/wiki/IBM_System/360
No doubt much work was done on IBM 7090/7094-class mainframes during the earlier parts of the Apollo project, but by the 1969 moon landing, most of the earlier machines would have been replaced with System\360 or similar mainframes from other vendors. In any event, there was much more compute power available during the Apollo project than slide rules!


